Definitionen nach den VARC-2-Kriterien
1 = schwerwiegende Blutungen (major bleedings): „Overt bleeding
either associated with a drop in the hemoglobin level of at least 3.0
g/dL or requiring transfusion of 2 or 3 units of whole blood/RBC, or
causing hospitalization or permanent injury, or requiring surgery AND
Does not meet criteria of life-threatening or disabling
bleeding“.
2 = lebensbedrohliche Blutungen (Life-threatening or disabling
bleedings): „Fatal bleeding OR Bleeding in a critical organ, such
as intracranial, intraspinal, intraocular, or pericardial necessitating
pericardiocentesis, or intramuscular with compartment syndrome OR
Bleeding causing hypovolaemic shock or severe hypotension requiring
vasopressors or surgery OR Overt source of bleeding with drop in
haemoglobin ≥5 g/dL or whole blood or packed red blood cells (RBCs)
transfusion ≥4 units“
Quelle: Updated standardized endpoint definitions for transcatheter
aortic valve implantation: The Valve Academic Research Consortium-2
consensus document. Kappetein, AP et al. (2012). European Heart Journal
33, 2403–2418 (S. 2409).