Definitionen nach den VARC-3-Kriterien

1 = schwerwiegende Blutungen (type 2): „Overt bleeding that requires a transfusion of 2–4 units of whole blood/red blood cells OR overt bleeding associated with a haemoglobin drop of >3 g/dL but <5 g/d"

2 = lebensbedrohliche Blutungen (type 3): „Overt bleeding in a critical organ, such as intracranial, intraspinal, intraocular, pericardial, or intramuscular with compartment syndrome OR overt bleeding causing hypovolemic shock or severe hypotension (systolic blood pressure <90 mmHg lasting >30 min and not responding to volume resuscitation) or requiring vasopressors or surgery OR overt bleeding requiring reoperation, surgical exploration, or re-intervention for the purpose of controlling bleeding OR Post-thoracotomy chest tube output ≥2 L within a 24-h period OR overt bleeding requiring a transfusion of ≥5 units of whole blood/red blood cells OR vert bleeding associated with a haemoglobin drop ≥5 g/dL“
Quelle: Valve Academic Research Consortium 3: Updated endpoint definitions for aortic valve clinical research. VARC-3 Writing Committee (2021). European Heart Journal 42 (19), 1825-1857 (S. 2723)